A new report reveals how a doctor who contracted Ebola in Sierra Leone was successfully treated with a drug called FX06, which has been shown to reduce vascular leakage in animal trials.
The 38-year-old man was managing an Ebola treatment unit in Sierra Leone when he developed fever and diarrhea on September 28th of this year. The same day, it was confirmed he had contracted Ebola.
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| A new report reveals how a doctor who contracted Ebola in Sierra Leone was successfully treated with a drug called FX06, which has been shown to reduce vascular leakage in animal trials. |
He was flown to Frankfurt University Hospital in Germany 5 days later, where he was placed in a specialized isolation unit and treated with an experimental drug called FX06 - a fibrin-derived peptide that has been shown to be effective in lowering vascular leakage in mice with Dengue hemorrhagic shock.
Dr. Timo Wolf and colleagues, of Frankfurt University Hospital, reveal how the man's treatment with the drug was a success, and they call for it to be assessed in clinical trials for Ebola.
No Ebola virus detected in blood 30 days after treatment with FX06
The patient showed signs of vascular leakage and failure of the lungs, kidneys and gastrointestinal tract, among other organs, within 72 hours of being admitted to the hospital.
After placing the patient on kidney dialysis and a ventilator, Dr. Wolf and colleagues gave him antibiotics and a 3-day treatment course with FX06 in order to prevent further vascular leakage.
Initially, the patient received 400 mg of FX06 intravenously - 200 mg were administered via a slow bolus injection (an injection that increases the concentration of a drug so it acts faster) and 10 minutes after, another 200-mg dose was given. The patient then received 200 mg of FX06 via an intravenous bolus injection every 12 hours thereafter for 3 days.
Following the treatment, Dr. Wolf and colleagues say they saw a significant improvement in the patient's respiratory and vascular function. This coincided with a reduced viral load in his blood. After 30 days, no Ebola virus could be detected. The doctor has now made a full recovery
We suggest FX06 as a potentially valuable therapeutic candidate for vascular leak syndrome in Ebola virus disease.
In view of the urgency for action in light of the current epidemic, where validated therapies are desperately needed, the efficacy of FX06 should soon be assessed in clinical trials or at least by standardized collection of data from patients with Ebola virus disease who received it in a compassionate use setting."
Ebola: the ongoing search for treatments
The global death toll from this year's Ebola outbreak is almost at 7,000, emphasizing the urgent need for ways to treat the disease. And researchers are certainly on the case.
The vaccine - which was tested on 20 people - appears to be safe, well tolerated and produces an effective immune response against Ebola virus disease, according to the study.
"The road is still long and there are many challenges, but we are nevertheless one step closer to a solution,
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